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Abstract
Phenothiazines are widely used in the treatment of certain psychiatric disorders. Overdoses of these drugs are common and are potentially lives threatening in patients admitted to emergency department of hospitals. This work aims to study the chromatographic and spectrophotometric behavior of some of commonly used phenothiazines (chlorpromazine hydrochloride and fluphenazine decanoate). Also for characterization of the different chemical groups of the studied drugs by using quick, sensitive and reliable method of analysis and for estimation of the drugs and their distribution among different tissues, hair and body fluids of albino rats.
The present study was conducted on ninety albino rats