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Abstract
Nephrotic syndrome has been recognized as one of the prothrombotic states in children .the incidence of thromboembolic complication in children ranges from 1.8% to5.3%.
Nephrotic syndrome has been recognized as one of the prothrombotic states in children. The incidence of thromboembolic complication in children ranges from 1.8% to 5.3% (Papachristou, et al. 2005). Several factors promoting thrombosis in nephrotic syndrome have been identified, including increased concentration of coagulation factors, impaired fibrinolysis, inflammation, increased platelet aggregation, hypovolemia, and immobilization (Niaudet, 1999). So our aim from this work is to assess platelet activation in nephrotic syndrome as a risk factor of thromboembolic complication by measuring platelet activation surface markers in whole blood using flow cytometry.
The study was conducted on 40 nephrotic patients 21 males and 19 females and 10 healthy control. They were subdivided after 1 month of treatment into 2 groups: group A (steroid responsive) includes 23 patients and group B (steroid resistant) includes 17 patients. They were subjected to the following investigation before treatment and after 1 month:
- Assessment of 24 h urinary protein, serum albumin, serum cholesterola and kidney function.
- Assay of prothrombin F1+2 and fibrinogen level.
- Platelets count.
- Flow cytometric analysis of selected markers of platelet activation CD61, CD62P and CD42b on platelet surface.
- Renal biopsy for steroid resistant cases.